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(39), the Bliss synergy score was defined as follows for reduced drug combinations: According to the Bliss criterion, when two independent drugs are combined, their effects simply add up, and the Bliss synergy score is zero

Using unapproved substances not only jeopardizes individual health but also raises ethical and legal issues, especially when medical professionals are involved

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Pemetrexed chemotherapy Pemetrexed belongs to a category of medications called antimetabolites, which work by inhibiting the production and repair of DNA in cancer cells, preventing their growth and reproduction